Studies on the erythropoiesis inhibiting factor in the plasma of animals with transfusion polycythemia.

Studies on the Erythropoiesis inhibiting Factor in the Plasma of Animals with Transfusion Polycythemia

I T HAS BEEN proved by many authors that polycythemia induced by blood transfusion reduces the peripheral reticulocyte count and inhibits erythropoiesis. #{176} In previous investigations on erythropoiesis We have observed that polycythemia causes the appearance in the plasma of an active substance, which is antagonistic to erythropoietin. The plasma obtained from polycythemic animals was injec...

Studies on erythropoiesis. XII. The effect of transfusion-induced polycythemia in the mother on the fetus.

Granulocytic recovery in the polycythemic dog treated with endotoxin postirradiation.

This experiment was designed to test the hypothesis that, in hypertransfused dogs with suppressed erythropoiesis, endotoxin-induced increased myelopoietic stimulation 24 hours after irradiation would enhance leukocytic recovery. The treatment combination of transfusion polycythemia and endotoxin was compared to a control group receiving no therapy or to the results obtained from groups of dogs ...

Plasma Erythropoietic Factor in Anemic Human Patients

By T. C. PRENTICE AND E. A. MIIIAND T HE EXISTENCE of a humoral erythropoietic stimulating factor which controls red cell productiomi has been suspected for mnamiy years. Carmiot amid I)eulamidre’ postulated in 1906 that such might be true. Imi 1950 Reissmanm, usimig paral)iotic rats, published convincing experimnental evidemice of a circubatimig erythropoietic factor imiduced by placimig one m...

The mechanism by which plethora suppresses erythropoiesis.

E RYTHROPOIETIN is believed to be the prime physiologic regulator of erythropoiesis.1 It is generally assumed that erythropoietin production is chiefly controlled by the demands of tissues for oxygen relative to their oxygen supply.1 According to this hypothesis transfusion-induced polycythemia results in suppression of erythropoietin production ( and consequently of erythropoiesis ) by virtue ...